The stage is set for one of the most anticipated NFL showdowns of the regular season. On Sunday, December 28, 2025, the Philadelphia Eagles will travel to Orchard Park, New York to take on the Buffalo Bills in a pivotal Week 17 matchup that could have major implications for playoff positioning. The game’s official kickoff time has now been confirmed.
Kickoff Set for Sunday Afternoon
The Eagles vs. Bills game will kick off at 4:25 p.m. Eastern Time at Highmark Stadium on Sunday, December 28. This classic Sunday afternoon time slot puts the matchup in the spotlight, with national television coverage on FOX for fans across the United States.
This Week 17 contest marks one of the final opportunities for both teams to solidify their standings as the 2025 NFL season winds toward its playoff crescendo.
What’s at Stake
Both the Eagles and the Bills come into this late-season clash with strong records and postseason aspirations. Philadelphia, riding momentum and striving for a top seed in the NFC, will be looking to carry late-season energy on the road. Meanwhile, Buffalo, solid at home and seeking to protect its playoff positioning in the AFC East, views this game as a statement performance.
A win for either squad could dramatically impact seeding scenarios in both conferences, making this matchup more than just a regular-season contest.
Key Storylines Heading Into the Game
Eagles’ Road Test in Orchard Park
The Eagles have shown resilience throughout the 2025 campaign. Between dynamic offensive playmaking and a defense capable of clutch stops, Philadelphia has positioned itself as one of the NFC’s most complete teams. With a 10–5 record entering Week 17, the Eagles will be looking to maintain their winning rhythm on the road in a hostile environment.
Quarterback leadership, red-zone execution, and minimizing turnovers will be essential if Philadelphia hopes to leave western New York with a victory.
Bills at Home: A Tough Challenge
Buffalo’s strong home field advantage at Highmark Stadium has been on full display this season. With an 11–4 record and a balanced offensive attack, the Bills are well-positioned to contend for a top playoff seed. Head Coach Sean McDermott’s club will look to control the game with a versatile offense and a defense that can make big plays when it matters most.
Expect Josh Allen and Buffalo’s key playmakers to take center stage as the team seeks a late-season boost before the postseason begins.
How to Watch
Fans planning to tune in can catch all the action on FOX beginning at 4:25 p.m. ET on Sunday, December 28. Local and national broadcast partners will bring live coverage, pre-game analysis, and expert commentary to millions of viewers nationwide.
Whether you’re watching from home or following the game while out and about, make sure to dial in early — pregame coverage typically begins at least an hour before kickoff.
Betting, Predictions, and Fan Buzz
Heading into the matchup, oddsmakers and analysts have been debating how this game might unfold. Recent prediction models show a tightly contested battle, with both teams’ strengths and weaknesses weighing into expectations. Some early projections even give the Eagles a slight advantage in certain statistical scenarios, highlighting just how competitive this Week 17 game is shaping up to be.
Fans and experts alike are already discussing key matchups — from Eagles pass protection to the Bills’ defensive adjustments — making this one of the most talked-about games of the week.
Final Thoughts: A Must-Watch Late-Season Clash
With kickoff time set for 4:25 p.m. ET at Highmark Stadium, the Eagles vs. Bills matchup on December 28, 2025, promises to be a thrilling conclusion to the regular season. Both teams have shown they can compete at a high level, and with significant playoff implications on the line, this game could easily be remembered as one of the defining moments of the 2025 NFL season.
Whether you’re a die-hard Eagles supporter, a loyal Bills fan, or a neutral observer looking for great football, this Week 17 showdown delivers all the drama, strategy, and excitement that makes the NFL the most compelling league in sports.
Stay tuned for more updates as we approach Sunday — and don’t forget: kickoff is at 4:25 p.m. Eastern Time on December 28!
