How to Watch: San Francisco 49ers vs. Indianapolis Colts – NFL Week 16 Showdown
The San Francisco 49ers (10-4) head east to face the Indianapolis Colts (8-6) in a pivotal interconference clash on Monday Night Football, closing out Week 16 of the 2025 NFL season. This prime-time matchup at Lucas Oil Stadium in Indianapolis pits two playoff hopefuls against each other, with the 49ers chasing NFC West supremacy and the Colts battling for an AFC wild-card spot.
Kickoff is set for 8:15 p.m. ET (5:15 p.m. PT) on Monday, December 22, 2025. Expect chilly conditions inside the domed Lucas Oil Stadium, where the roof could remain closed for optimal playing surface.
Nationally, the game broadcasts on ESPN and simulcasts on ABC, making it widely accessible over the air. Joe Buck and Troy Aikman call the action in the booth, with Lisa Salters and Laura Rutledge handling sideline reports. For Spanish-language viewers, tune into ESPN Deportes.
This marks a special expanded Monday Night Football presentation, also streaming live on Disney+ for standalone subscribers—a rare addition that broadens reach beyond traditional cable.
Streaming options abound for cord-cutters. Watch via NFL+ (mobile devices only for live games), YouTube TV, Hulu + Live TV, FuboTV (with free trial available), or Sling TV. International fans can catch it on NFL Game Pass via DAZN.
Pre-game coverage starts early on ESPN with Monday Night Countdown at 6:00 p.m. ET, featuring insider analysis on Brock Purdy’s efficiency against a resilient Colts defense led by veteran quarterback Philip Rivers in his comeback season.
Radio listeners can tune in locally—49ers flagship KNBR 680 AM/104.5 FM in the Bay Area, or Colts’ WFNI 1070 The Fan in Indianapolis. SiriusXM offers channels for both home and away feeds.
As the final game of Week 16, this matchup carries massive playoff implications. Don’t miss what promises to be a hard-hitting, strategic battle under the Monday night lights—tune in and witness the drama unfold.
