How to Watch San Francisco 49ers at Arizona Cardinals: TV Channel and Streaming Options for September 21

The San Francisco 49ers take on the Arizona Cardinals on Saturday, September 21, 2025, in a thrilling NFC West showdown during Week 3 of the NFL season. With the 49ers looking to dominate the division and the Cardinals aiming to upset with Kyler Murray’s dynamic play, this game at State Farm Stadium in Glendale, Arizona, is a must-see. Kickoff is set for 8:15 PM ET (5:15 PM PT), part of a rare Saturday night NFL slot. Here’s your complete guide to watching the game on TV and streaming platforms.

Game Details

Away Team: San Francisco 49ers.
Home Team: Arizona Cardinals (State Farm Stadium, Glendale, AZ).
Date and Time: 8:15 PM ET / 5:15 PM PT (September 21, 2025).
Venue: State Farm Stadium, Glendale.
Weather Forecast: Indoor stadium with a retractable roof, ensuring perfect conditions.

This primetime divisional matchup pits the 49ers’ high-powered offense against a Cardinals team eager to climb the NFC West standings.

TV Channels

The game will be broadcast nationally in the U.S., accessible via cable, satellite, or over-the-air antennas in select markets.

NBC: As a primetime Saturday game, NBC holds the broadcast rights. Expect commentary from broadcasters like Mike Tirico and Cris Collinsworth, with sideline reports. NBC is available through most cable providers (e.g., Comcast, DirecTV, Dish Network) and OTA antennas in many areas.
Local Affiliates:
- Phoenix (Cardinals): KPNX (NBC 12) will air the game locally, with radio coverage on Arizona Sports 98.7 FM.
- San Francisco (49ers): KNTV (NBC Bay Area) will broadcast locally, with radio on KNBR 680 AM/104.5 FM.
Spanish-Language Option: NBC Universo or local affiliates may offer Spanish-language commentary.

Note: International viewers, including those in Vietnam (where kickoff is 7:15 AM on September 22, 2025, +07), may face regional restrictions. A VPN can help access U.S. broadcasts.

Streaming Options

Streaming services offer flexible ways to watch the game without cable. Most platforms require a subscription, but some provide free trials.

Peacock: NBC’s streaming service will stream the game live. Peacock Premium (starting at $7.99/month) includes NFL games and exclusive content. Available on iOS, Android, Roku, Fire TV, and more, with HD quality and multi-device support.
NBC Sports App or Website: Stream with a TV provider login (cable or streaming service). Compatible with most devices and ideal for in-market viewers.
Live TV Streaming Services (Great for cord-cutters):
- YouTube TV: Includes NBC and other NFL channels (approx. $72.99/month). Offers unlimited cloud DVR and a free trial, perfect for multiviewing.
- Hulu + Live TV: Carries NBC, ESPN, and the Disney Bundle (approx. $76.99/month). Excellent for highlights and on-demand content.
- FuboTV: Sports-focused, includes NBC (approx. $79.99/month). Features NFL RedZone for additional Week 3 action and a free trial.
- Sling TV: Blue package includes NBC in select markets ($40/month). Budget-friendly with add-ons for more sports channels.
- DirecTV Stream: Choice package includes NBC (approx. $108.99/month). Reliable but more expensive.
NFL+: The NFL’s official app offers mobile streaming for primetime games ($6.99/month). Limited to phones/tablets unless upgraded to NFL+ Premium ($14.99/month) for replays and all-22 film. In-market availability depends on local broadcast rules.
International Viewers: Use NFL Game Pass International (via DAZN in some regions) for global access, or NFL+ Premium. In Vietnam, consider FuboTV or a VPN connected to a U.S. server to access Peacock or YouTube TV.
Additional Notes: Avoid unofficial streams due to potential quality issues or legal risks. Paramount+ or ESPN+ won’t carry this game live (not on CBS or ESPN).

Viewing Tips

Devices: Watch on smart TVs, computers, streaming sticks, or mobile devices. Ensure a stable internet connection (minimum 5 Mbps for HD).
VPN: Services like ExpressVPN or NordVPN can bypass geo-restrictions for U.S.-based streams.
Radio and Audio: Listen live on SiriusXM NFL Radio (Channel 88 for 49ers, 225 for Cardinals) or the NFL app for real-time commentary.
Highlights and Replays: Post-game, find free highlights on NFL.com, YouTube, or the NBC Sports app. Full replays are available on NFL+ Premium or Peacock.

Don’t miss this critical NFC West battle that could set the tone for the 2025 season! For tickets, stats, or predictions, visit the NFL or team websites.