How to Watch San Francisco 49ers vs Arizona Cardinals: 2025 NFL Season Opener – Week 3
The San Francisco 49ers and Arizona Cardinals are set to clash in a highly anticipated NFC West showdown during Week 3 of the 2025 NFL season. Both teams enter the matchup undefeated at 2-0, making this game a pivotal early test for divisional supremacy. The 49ers, fresh off a 26-21 road win against the New Orleans Saints—where backup QB Mac Jones threw for 279 yards and three touchdowns in place of the injured Brock Purdy—return home to Levi’s Stadium. Meanwhile, the Cardinals notched a 27-22 victory over the Carolina Panthers in their home opener, with Kyler Murray showcasing his dual-threat prowess.
This “house money” battle, as previewed by NFL analysts, could see the winner solidify their status as a legitimate contender. With the 49ers favored by 1.5 points and an over/under of 45.5, expect a high-energy affair featuring San Francisco’s dynamic ground game against Arizona’s opportunistic secondary. Here’s everything you need to know to catch the action live.
Game Details
- Date: Sunday, September 21, 2025
- Time: 4:25 p.m. ET (1:25 p.m. PT / 1:25 p.m. MST)
- Location: Levi’s Stadium, Santa Clara, California
- Teams’ Records: 49ers (2-0), Cardinals (2-0)
- Broadcast Network: FOX (regional coverage for the West Coast and Southwest markets)
- Announcers: Kevin Burkhardt (play-by-play), Tom Rinaldi (analyst), and Erin Andrews (sideline) on FOX
TV Broadcast
The game will air live on FOX, the primary network for NFC matchups like this one. If you’re in the 49ers’ or Cardinals’ broadcast markets (including California, Arizona, and surrounding states), tune in via your local FOX affiliate. Pre-game coverage kicks off at 8:30 a.m. PT with Cardinals-specific shows like “Cardinals Early Bird” and “The Arizona Cardinals Pregame Huddle,” leading into FOX’s national NFL coverage.
To confirm your local channel, check your cable/satellite provider’s lineup or use FOX’s online channel finder.
Streaming Options
Can’t make it to a TV? Stream the game live through these platforms:
- Fubo: Offers FOX in its base package with a free trial available—perfect for sports fans with DVR capabilities.
- YouTube TV: Includes FOX and unlimited cloud DVR for $72.99/month (free trial for new users).
- Hulu + Live TV: Bundles FOX with Hulu’s on-demand library for $76.99/month (includes a 3-day free trial).
- Sling TV: Affordable option with FOX in the Sling Blue package starting at $40/month.
- NFL+: Mobile streaming for in-market and out-of-market games (basic plan $6.99/month; Premium adds NFL RedZone and condensed replays).
- DAZN: International viewers can access the game via NFL Game Pass on DAZN (subscription required outside the US).
Note: Out-of-market viewers may need a VPN or NFL Sunday Ticket (via YouTube TV) for unrestricted access, though this game is regionally blacked out on FOX.
Radio Broadcast
For audio-only listening:
- 49ers Radio Network: KNBR 680 AM/1050 AM in the Bay Area, with Greg Papa and Tim Ryan on the call. Stream free at 49ers.com/esp.
- Cardinals Radio Network: Arizona Sports 98.7 FM in Phoenix, featuring Dave Pasch and A.Q. Shipley. Available statewide.
- National: ESPN Radio with Chris Carlin and Kelly Stouffer providing commentary.
- NFL+ App: Stream the radio feed on mobile devices.
Mobile Apps and Highlights
- Download the NFL App or FOX Sports App for live updates, real-time scores, and post-game highlights.
- ESPN App: Follow along with live stats, player tracking, and expert analysis from the game page.
- Post-game: Full replays and condensed versions available on NFL+ Premium or YouTube (search for official NFL uploads).
Tickets and In-Person Viewing
If you’re heading to Levi’s Stadium, tickets are still available starting at around $123 for upper-level seats, with premium options from $315. Purchase via official sites like Ticketmaster, SeatGeek, or the teams’ websites. Tailgating is encouraged—arrive early for parking and pre-game festivities.
Quick Betting Odds (via BetMGM)
- Spread: 49ers -1.5 (-125) / Cardinals +1.5 (-105)
- Moneyline: 49ers -150 / Cardinals +130
- Total: Over/Under 45.5 (O -115 / U -105)
This Week 3 thriller promises fireworks from stars like Murray’s scrambling and the 49ers’ revamped offense. Whether streaming from your couch or cheering live, gear up for an NFC West classic. Who ya got?
