Broadcast & Streaming Info
The 49ers travel to take on the Cardinals on Sunday, November 16, 2025, at State Farm Stadium in Glendale, Arizona. According to local listings, kickoff is set for 2:05 p.m. Mountain Standard Time (MST). azcardinals.com+1
The game will be televised nationally on FOX. Goal+249ers Webzone+2
Streaming options include the Fox Sports app (in-market) and platforms that carry FOX live. Also, for out-of-market viewers, services such as NFL + or NFL Game Pass may be used. azcardinals.com+1

Injury Report & Player Availability
Both teams arrive with significant injury concerns.

Cardinals: The injury list is long. Key absences include rookie WR Marvin Harrison Jr., who is out after surgery for appendicitis. The Times of India+1 Other players missing or limited include OL Kelvin Beachum (rest/groin), LB Baron Browning (concussion), CB Will Johnson (back/hip), OL Jonah Williams (shoulder), RB Bam Knight (ankle), among several others. azcardinals.com+1
49ers: The 49ers are getting healthier and reportedly will have QB Brock Purdy back after missing time due to toe injury. CBS Sports+1 Meanwhile, WR Ricky Pearsall (knee) is limited and other contributors are working back. SI

Match-Up & Game Preview
This is a classic NFC West divisional clash. The 49ers (currently 6-4) are vying for positioning in the playoff race, while the Cardinals (3-6) are fighting to salvage pride and rebuild momentum.

For San Francisco, having Brock Purdy back is huge — his presence gives the offense more structure and scoring potential than the backup arrangement. On defense, the 49ers will look to exploit Arizona’s weakened line and secondary.

For Arizona, the absence of Marvin Harrison Jr. is a blow to their offense, and the extensive injury list across both offensive and defensive units complicates matters. Their home turf gives them a chance, but the depth and overall roster health tilt in San Francisco’s favour.

Key tactical battles:

• 49ers’ offensive line vs. Cardinals’ pass rush: If the 49ers protect Purdy and establish the run early, they can control the tempo.

• Cardinals’ ability to generate big plays and force turnovers: With missing pieces, they need to create splash moments to stay in the game.

• Divisional stakes: The 49ers can gain a valuable sweep of the season against a division rival; the Cardinals need a win to inject confidence into their season.