The Carolina Panthers (4–3) are putting their three-game winning streak on the line as they host the Buffalo Bills (4–2) in Week 8. Both teams are battling for momentum in the middle of the AFC and NFC playoff picture, making this matchup one to watch closely.

Fans can stream the action live through Fubo (in-market viewers) or catch the broadcast on FOX. Those attending in person can secure tickets through StubHub to experience the atmosphere at

Bank of America Stadium.

Buffalo vs. Carolina Odds (via BetMGM)

• Spread: Buffalo –7.5 (–105), Carolina +7.5 (–115)

• Favorite Moneyline: Buffalo –400

• Underdog Moneyline: Carolina +310

• Total: 45.5

• Over Odds:

  –110

• Under Odds: –110

Injury Reports

• Bills: No injuries listed

• Panthers: No injuries listed

Stats to Know

• The Bills average 27.8 points per game, outscoring what the Panthers typically allow (

  21.7) by 6.1 points.

• Carolina’s defense has allowed 295.7 yards per game, which is 82.6 fewer yards than Buffalo’s offense has generated (378.3). Buffalo averages

  6.2 yards per play, while Carolina allows 5.5.

• The Panthers’ offense averages 20.7 points per game, while Buffalo’s defense allows 22.8, a difference of just 2.1 points

  .

• Carolina’s offense posts 326.7 yards per game, nearly even with the 323.5 yards Buffalo’s defense gives up. The Panthers average 5.2 yards per play, and Buffalo gives up

  5.9.

This game preview was created using data provided by Data Skrive.
Betting, odds, and streaming details are provided by partners of The Athletic. Restrictions may apply.

Game Information

• Matchup: Buffalo Bills (4–2) vs. Carolina Panthers (4–3)

• Venue: Bank of America Stadium, Charlotte, NC

• Date: Sunday, October 26, 2025

• Time: 1:00 p.m. ET