BREAKING: 49ers Injury Report Hints at Who the Starting QB Will Be vs. Rams

The San Francisco 49ers are facing one of their earliest and most intriguing tests of the season, as they prepare to take on the Los Angeles Rams in what could be a crucial NFC West showdown. But the biggest question swirling around Levi’s Stadium this week isn’t about game planning, defensive adjustments, or the Rams’ explosive offense. Instead, it’s all about the quarterback position. A fresh injury report released Thursday has provided a major clue about who will lead the 49ers’ offense on Sunday.
For weeks, there has been speculation over who would emerge as the starter under center. With Brock Purdy, Trey Lance (before his trade), and Sam Darnold once all part of the conversation, the position has been under a microscope in San Francisco. Now, with Purdy firmly established as the team’s starter last year, lingering health concerns have left room for questions once again.
This week’s injury report was supposed to be routine. But when the update showed that Purdy was limited in practice due to soreness in his throwing arm, eyebrows immediately raised. While the team has downplayed the severity of his discomfort, insiders noted that backup Sam Darnold took the majority of first-team reps in practice — a clear sign that the 49ers may be preparing for a contingency plan.
Head coach Kyle Shanahan, as usual, played his cards close to his chest when asked directly about who would start on Sunday. “We’ll see how the week goes,” Shanahan said at the podium, “Brock’s a tough kid, and we’re confident in him. But we’ve got to be smart about the long season ahead. We trust all our quarterbacks to step up if needed.”
The phrasing is telling. Shanahan’s tone didn’t rule Purdy out, but it also subtly acknowledged that a decision might come down to game-time evaluation. Injury reports often reveal more than coaches want to admit publicly, and in this case, the 49ers may be bracing for Darnold to make his first start as a Niner.
For 49ers fans, this stirs mixed emotions. On one hand, Purdy has quickly become a fan favorite, with his underdog rise from “Mr. Irrelevant” to leading San Francisco deep into the postseason in 2022 still fresh in memory. His poise, accuracy, and leadership make him the kind of quarterback Shanahan loves to build around. On the other hand, the team has invested in Sam Darnold for situations exactly like this.
Darnold, the former No. 3 overall pick in the 2018 draft, never quite lived up to the hype with the Jets or Panthers. But he has shown flashes of talent, and many insiders believe Shanahan’s system could maximize his abilities. Known for creating quarterback-friendly schemes, Shanahan could give Darnold the fresh start he’s been looking for.

The Rams, of course, are closely monitoring this situation. Defensive coordinator Raheem Morris admitted that they’ve prepared two separate game plans — one for Purdy, one for Darnold. “They’re both capable,” Morris said. “Purdy’s shown what he can do in big games, and Darnold has the arm talent to hurt you if you’re not disciplined. We have to be ready for either.”
Adding another layer of intrigue, wide receiver Deebo Samuel was also listed as limited on the injury report due to rib soreness. If both Purdy and Samuel are not at full strength, the 49ers’ offense could look very different. Christian McCaffrey may be asked to shoulder an even larger workload against a Rams defense that has been stingy against the run.
For now, the atmosphere in Santa Clara is one of cautious optimism. Purdy was seen lightly throwing during Thursday’s walkthrough, suggesting the injury isn’t catastrophic. Still, Shanahan and the medical staff may choose to be conservative, especially this early in the season. No one wants to risk aggravating a minor issue into something long-term.
As Sunday approaches, fans should keep a close eye on Friday’s and Saturday’s practice reports. The NFL requires official designations of “questionable,” “doubtful,” or “out” before game day, and those tags will be critical in determining whether Purdy suits up or if Darnold gets his chance to lead the 49ers against their division rivals.
In the grand scheme of the season, this game could have playoff implications. The NFC West is one of the most competitive divisions in football, with the Rams, 49ers, and Seahawks all fighting for supremacy. A win here could set the tone for the months ahead.
For now, the mystery lingers. Will it be Brock Purdy, the young star who has already proven he belongs, or Sam Darnold, the talented but unfulfilled quarterback hoping for redemption? Thanks to the latest injury report, we may already have our answer — but the final decision won’t be made until kickoff in Los Angeles.
One thing is certain: all eyes will be on the 49ers’ sideline when the offense takes the field.