How to Watch San Francisco 49ers at Arizona Cardinals: TV Channel and Streaming Options for September 21
Football fans across the nation are eagerly anticipating one of the most intriguing matchups of Week 3 in the 2025 NFL season: the San Francisco 49ers traveling to Glendale, Arizona, to take on the Arizona Cardinals. The game is scheduled for Sunday, September 21, and it is already generating buzz as both teams are looking to make a statement early in the season. Whether you’re a die-hard fan of the 49ers, a loyal supporter of the Cardinals, or simply a football enthusiast looking for an exciting showdown, knowing how and where to watch the game is essential.
This guide will break down all the TV channels, streaming services, kickoff times, and other key details so you won’t miss a single snap.
Kickoff Time and Venue
The game between the San Francisco 49ers and Arizona Cardinals will be played at State Farm Stadium in Glendale, Arizona. Kickoff is set for 4:25 p.m. ET (1:25 p.m. PT) on Sunday, September 21. Afternoon games like this often draw a massive national audience, and this matchup has been slotted as one of the featured contests of the week.
TV Channel Information
The broadcasting rights for this game fall under FOX’s NFL coverage. Fans across most markets will be able to tune in through their local FOX affiliate. FOX’s broadcast crew, which typically includes a play-by-play commentator, color analyst, and sideline reporters, will provide in-depth coverage, instant replays, and expert analysis throughout the contest.
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National TV Channel: FOX
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Local Markets: Bay Area (San Francisco), Phoenix/Glendale (Arizona), and many surrounding regions will receive the game as the featured broadcast.
If you’re watching through traditional cable or satellite, check your local listings to confirm the channel.
Streaming Options
For fans who prefer to stream the game rather than watch on traditional TV, there are several reliable options:
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FOX Sports App – If you already have a cable or satellite subscription that includes FOX, you can log in with your provider credentials and stream the game live on the FOX Sports app or website.
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NFL+ – The NFL’s own streaming service allows fans to watch live local and primetime games on mobile devices and tablets. NFL+ also offers replays and condensed versions of games for those who can’t watch live.
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Hulu + Live TV – This service includes FOX in its channel lineup in most markets, making it a great option for cord-cutters who want live sports and entertainment.
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YouTube TV – Another strong streaming option, offering FOX nationwide with unlimited DVR so fans can record the game and watch later.
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FuboTV – Known for its sports-heavy programming, FuboTV carries FOX and provides additional features like multi-screen viewing.
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Sling TV (Blue Package) – Sling Blue offers FOX in select markets, so fans should confirm availability before game day.
What to Watch For
Beyond just knowing how to watch, fans are eager to see how these two NFC West rivals perform on the field.
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San Francisco 49ers: Led by quarterback Brock Purdy, star tight end George Kittle, and dynamic running back Christian McCaffrey, the 49ers enter the season as one of the NFC’s strongest contenders. Their defense, anchored by Nick Bosa and Fred Warner, continues to be one of the most feared units in the league.
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Arizona Cardinals: The Cardinals are in a rebuilding phase but still boast explosive playmakers. Quarterback Kyler Murray, if fully healthy, is always a threat with both his arm and legs. Wide receiver Michael Wilson and running back James Conner give Arizona key offensive options. Playing at home in Glendale also provides an energy boost for the Cardinals.
This divisional battle could have long-term implications in the NFC West standings. The 49ers aim to solidify their position as favorites, while the Cardinals hope to pull off an upset and prove they can compete against one of the league’s top teams.
Why This Matchup Matters
The 49ers–Cardinals rivalry has produced memorable moments over the years. Although San Francisco has dominated in recent seasons, divisional matchups are often unpredictable. Every win or loss within the division carries extra weight, especially for teams chasing playoff positioning. Fans can expect a high-intensity contest filled with physical play, strategic battles, and plenty of drama.
Final Thoughts
Whether you choose to watch on FOX through traditional television or prefer one of the many streaming options like YouTube TV, Hulu + Live TV, or the FOX Sports app, there’s no shortage of ways to catch the action. Mark your calendars for Sunday, September 21 at 4:25 p.m. ET, and get ready to watch the San Francisco 49ers face off against the Arizona Cardinals at State Farm Stadium.
For fans of both teams, this game represents more than just another date on the schedule—it’s a chance to see where each franchise stands early in the 2025 NFL season. Make sure you don’t miss it.
